An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs

Valerie C. Clark*, Liva Harinantenaina, Martin Zeller§, William Ronto, James Rocca, Aaron T. Dossey, Daniel Rakotondravony, David G. I. Kingston, and Chris Shaw
School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States
§ Thermo Fisher Scientific, 28199 Bremen, Germany
Department of Animal Biology, University of Antananarivo, Antananarivo 101, Madagascar
AMRIS Facility, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, United States
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32607, United States
J. Nat. Prod., Article ASAP
DOI: 10.1021/np200963r
Publication Date (Web): January 30, 2012


The skins of Madagascar poison frogs (Mantella) and certain Neotropical poison frogs (Epipedobates, Dendrobates) secrete the new bile acid tauromantellic acid (1), which was found in both wild-caught and captive-born frogs. This is the first molecule of endogenous origin detected in skin secretions from these taxa. Sucrose was also detected in secretions from wild-caught Mantella but not in captive-born frogs, suggesting a dietary origin.

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Unknown on July 14, 2012 at 12:04 AM said...

As we know that Plant extract of cucumber is a vegetable that belongs to the same family as pumpkins, zucchinis and other squashes. It has a dark green skin, which reveals whitish or very light green flesh, when peeled.

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