Bioactive Carbazole Alkaloids from Clausena wallichii Roots

Wisanu Maneerat†, Thunwadee Ritthiwigrom‡, Sarot Cheenpracha§, Trinop Promgool†, Kulsiri Yossathera†, Suwanna Deachathai†, Wong Phakhodee†, and Surat Laphookhieo*†
† Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand
‡ Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand
§ School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand
J. Nat. Prod., Article ASAP
DOI: 10.1021/np3000365
Publication Date (Web): April 6, 2012
Copyright © 2012 The American Chemical Society and American Society of Pharmacognosy

clausenawallines C–F

Four new carbazole alkaloids, clausenawallines C–F (14), along with 18 known compounds (522) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4–16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 μM, respectively.

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