Triterpenoid glucuronide saponins from root bark of aralia armata

Mei Hu, Kazunori Ogawa, Yutaka Sashida Xiao Pei-Gen (1995), Triterpenoid glucuronide saponins from root bark of aralia armata, Phytochemistry, Volume 39, Issue 1,  P.179-184

Abstract

Seventeen oleanane-type saponins were isolated from the root bark of Aralia armata. Their structures were elucidated by chemical and spectral evidence. Except for oleanolic acid 28-O-β-D-glucopyranoside all the saponins have a glucuronopyranosyl residue at the C-3 position of the aglycones and other sugar substitutes bind to glucuronic acid at positions C-3 and/or C-4. A comparison of saponin constituents of this plant with other araliaceous plants is provided.

Keywords

Aralia armata; Araliaceae; root bark; triterpenoid saponin; oleanolic acid glucuronide

INTRODUCTION

It  is  known  that  the  roots  of several members  of Aralia species have been used as folk medicines for rheumatism, tonic  and diabetes  in  China,  Japan  and  Russia.  In  the early  part  of  the  sixties,  Kochetkov  et al.  [1]  isolated physiologically  active  saponins,  aralosides  A,  B  and C,  first  from  this  genus.  Many  triterpenoid  saponins
have  recently  been  isolated  from  several  Aralia  species [2-9].  A. armata (Wall.) Seem.  is  one of common herbal medicines  of  the  genus  Aralia  in  China.  No  chemical work, however, has been done on  this plant. The present paper  deals  with  the  isolation  and  structure  determination of16 oleanolic acid-based saponins along with a minor  saponin  of hederagenin  from  the  root  bark  of  this plant.

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