Serotonin-Synonyms 5-Hydroxytryptamine; 5-HT; Enteramine; Thrombocytin; Thrombotonin

A. Serotonin


Synonyms 5-Hydroxytryptamine; 5-HT; Enteramine; Thrombocytin; Thrombotonin;
Biological Sources The root bark of Gossypium hirsutum L. (Malvaceae) (American Unplanted
Cotton) contains serotonin.
Chemical Structure

Serotonin
3-(2-Aminoethyl)-1H-indol-5-ol; (C10H12N2O).
Identification Tests
1. Serotonin Hydrochloride (C10H12N2O.HCl) It is obtained as hygroscopic crystals, sensitive to light having mp 167-168°C. It is water soluble and the aqueous solutions are found to be stable at pH 2-6.4.
2. Serotonin complex with Creatinine Sulphate Monohydrate (C14H21 N5O6S.H2O)
(Antemovis) It is obtained as plates which decomposes at 215°C. Its uvmax (water at pH 3.5): is 275 nm (ε 15,000). It has two dissociation constants pK1' = 4.9 and pK2' = 9.8. The pH of a 0.01 molar aqueous solution is 3.6. It is found to be soluble in glacial acetic acid; very sparingly soluble in methanol and ethanol (95%); and insoluble in absolute ethanol, acetone, pyridine, ethyl acetate, chloroform, benzene and ether.
Uses
1. It is a potent vasoconstrictor.
2. It is also a neurotransmitter in the CNS and is important in sleep-walking-cycles.

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