Abstract:
The leaves of Ficus pumila afforded a new neohopane
(1) by silica gel chromatography. The structure of 1 was elucidated by 1D and
2D NMR and IR spectroscopy and mass spectrometry. It showed antimicrobial
activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis
and Candida albicans with an average antimicrobial index of 0.5, 0.3, 0.3 and
0.7, respectively, at a concentration of 30 microg.
INTRODUCTION:
Ficus pumila or
creeping fig, an ornamental plant of the family Moraceae grows vigorously in
adobe and concrete walls throughout the Philippines. Its leaves are used in the
treatment of dysentery and haematuria, while the juice is employed to treat
skin diseases. Previous studies on Ficus pumila reported the isolation of 1,4-poIyisoprenes [2], amyrin acetate, mesoinositol, rutin,
sitosterol and taraxenyl acetate [3] and the flavonoids, bergapten and oxypeucedanin
hydrate [4]. We now report the isolation, structure elucidation and
antimicrobial test results of a new neohopane triterpene (1) from the
chloroform extract of Ficus pumila
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