A triterpene from Ficus pumila

Ragasa CY, Juan E, Rideout JA.A triterpene from Ficus pumila (1999), Journal of Asian Natural Products A triterpene from Ficus pumila Research, 1:4, 269-275

The leaves of Ficus pumila afforded a new neohopane (1) by silica gel chromatography. The structure of 1 was elucidated by 1D and 2D NMR and IR spectroscopy and mass spectrometry. It showed antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans with an average antimicrobial index of 0.5, 0.3, 0.3 and 0.7, respectively, at a concentration of 30 microg.
Ficus pumila or creeping fig, an ornamental plant of the family Moraceae grows vigorously in adobe and concrete walls throughout the Philippines. Its leaves are used in the treatment of dysentery and haematuria, while the juice is employed to treat skin diseases. Previous studies on Ficus pumila reported the isolation of 1,4-poIyisoprenes [2], amyrin acetate, mesoinositol, rutin, sitosterol and taraxenyl acetate [3] and the flavonoids, bergapten and oxypeucedanin hydrate [4]. We now report the isolation, structure elucidation and antimicrobial test results of a new neohopane triterpene (1) from the chloroform extract of Ficus pumila

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