Exploration of Biological–Active–Prototypes towards Newer and Better Synthetic Drugs

2.3. Exploration of Biological–Active–Prototypes towards Newer and Better Synthetic Drugs
A plethora of better synthetic drug models gained considerable recognition in the therapeutic arsenal that were solely derived on the biologically-active-prototypes. It is, however, pertinent to mention here that these synthetic models not only possessed similar and better therapeutic index but also

Note: The dotted areas in the above chemical structures show the presence of essential characteristic features in
the natural (biological-active-prototype), semisynthetic and synthetic models.
exhibited fewer side effects than their corresponding naturally occurring constituents. A few typical examples are enumerated below:

REFERENCES
Ashutosh Kar (2003), Pharmacognosy and Pharmaco biotechnology, 2nd Edition
‘Handbook of Medicinal Herbs’ (2001), J.A. Duke, CRC-Press, London, 1st Edn.
William Charles Evans (2002), Trease and Evans Pharmacognosy 15th Edition by: Trease, Bailliere Tindall; Evans.
Ramstad (1956), E., ‘Modern Pharmacognosy’, McGraw Hill, London.

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